PRELIMINARY RESULTS OF lncRNAs AS BIOMARKERS FOR COLORECTAL CANCER DIAGNOSIS

Abstract Introduction lncRNAs are strands larger than 200 nucleotides that do not encode proteins. They have regulatory functions in cell proliferation, apoptosis and migration. stable over a long period may diagnostic value colorectal cancer (CRC). Their availability as effective biomarkers for CRC screening would represent substantial advance, tests could be performed with minimal risk wide acceptance. The aim of this study is to evaluate selected plasma potential CRC. Methods Prospective cohort between patients operated on (cases) healthy (controls). Blood samples were processed the biobank obtain by centrifugation. Subsequently, levels three CRC-related (HOTAIR, CCAT2 PVT1) determined laboratory Electroanalysis Group University Oviedo (GEUO). Results In initial results, an overexpression genes was observed patients, HOTAIR being one best differentiates patients. addition, combined determination better results individual each them. Conclusions studied overexpressed patient sample. sample size needs increased confirm trend. It logical postulate molecular technologies will lead development modalities individualised treatments.